Expression of NM23 in human melanoma progression and metastasis
نویسندگان
چکیده
منابع مشابه
Association between NM23-H1 gene expression and metastasis of human uveal melanoma in an animal model.
PURPOSE To evaluate the role of nm23 gene expression in the development of metastases of human uveal melanomas in an animal model. METHODS Seven human uveal melanoma cell lines and two murine skin melanoma cell lines were subjected to Northern blot analysis for the detection of nm23-H1 mRNA and to immuno-histochemistry to detect nm23 antigen. Each tumor cell line was transplanted intracameral...
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The Nm23 gene is a metastatic suppressor identified in a melanoma cell line and expressed in different tumors where their levels of expression are associated with reduced or increased metastatic potential. Nm23 is one of the over 20 metastasis suppressor genes (MSGs) confirmed in vivo. It is highly conserved from yeast to human, implying a critical developmental function. Tumors with alteration...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1996
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1996.323